Prothrombin gene variants
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About Prothrombin – rs1799963, rs3136516
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About Prothrombin – rs1799963, rs3136516
Overview and History
Prothrombin – rs1799963 and rs3136516 are single-nucleotide polymorphisms (SNPs) in the F2 gene, which encodes prothrombin (factor II). Prothrombin is a liver-produced zymogen that is converted to thrombin during clotting; changes in the F2 gene can affect mRNA processing or expression and thus modestly alter circulating prothrombin levels.
Historically, rs1799963 (often reported as G20210A) was identified as a variant associated with higher prothrombin levels in population studies. Rs3136516 has also been studied for its influence on prothrombin expression. These variants are genetic markers that provide inherited-context information rather than definitive functional readouts on their own.
Interpreting Highs and Lows
Elevated prothrombin-related signals or the presence of prothrombin-increasing variants may be associated with higher circulating prothrombin or stronger activation signals in clotting pathways. Such findings can reflect inherited genetic effects but may also be influenced by concurrent factors like inflammation, hormone states, liver function, or other genetic variants.
Lower prothrombin signals or absence of prothrombin-increasing variants may reflect normal genetic background or reduced prothrombin production from non-genetic causes (for example, impaired liver synthesis or systemic factors). Interpretation is most accurate when combined with the Cardio Zoomer panel’s clotting markers, liver tests, inflammatory markers, and clinical context.
Featured Test
Cardio Zoomer includes these F2 variants to add an inherited-clotting dimension to the panel. They help explain why clotting markers or prothrombin levels may deviate from expectation and guide interpretation alongside inflammation, liver function, and other coagulation measures—supporting more personalized risk pattern recognition and monitoring.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
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MSc- MHNE- Clinical Educator
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MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
