Wnt-pathway transcription factor SNPs
Quality and Security
High-quality testing run in a CLIA-certified and CAP-accredited lab in Santa Clara, California.
About TCF7L2 – rs7903146, rs12255372
${ activeTab.tab_content.text }
Loading...
About TCF7L2 – rs7903146, rs12255372
Overview and History
TCF7L2 encodes a transcription factor that participates in Wnt signaling, a cellular pathway that helps control gene expression programs in many tissues. Biochemically it is a DNA-binding regulatory protein; the specific markers reported here are single-nucleotide polymorphisms (SNPs) within the TCF7L2 locus.
These two SNPs, rs7903146 and rs12255372, were highlighted in large genetic association studies for links to glycemic traits and metabolic signaling. Research suggests TCF7L2 variants can influence gene networks involved in insulin secretion, incretin responses, and cellular metabolism, making them useful population-level markers of inherited metabolic tendency rather than deterministic predictors of outcome.
Interpreting Highs and Lows
For genetic variants like these, “elevated” typically means carriage of one or more risk-associated alleles, while “low” means absence of those alleles. Presence of risk alleles has been associated with altered insulin-secretory patterns and differences in glucose-regulatory signaling; absence of risk alleles suggests less inherited contribution from TCF7L2 to those specific pathways.
Interpretation requires the full Cardio Zoomer profile: these variants provide inherited context that should be read alongside metabolic labs, lipid measures, inflammatory markers, and clinical history, since genes act together with environment and physiology.
Featured Test
TCF7L2 variants are included to document inherited effects on glucose regulation and related metabolic pathways that interact with cardiovascular health. In Cardio Zoomer they add genetic context to biochemical markers, helping clinicians distinguish inherited tendency from current metabolic state and better explain individual biomarker patterns.
Related Articles
Cardiovascular disease remains the leading cause of death worldwide, yet most testing still focuses on surface-level metrics like total cholesterol or...
What do you think of when you hear the term “cardiovascular disease?” Most people immediately think of high cholesterol, but cardiovascular risk goes ...
A common theme among many of my nutrition clients is that despite eating well, staying active, and managing stress, they feel worn down, inflamed, and...
When it comes to cardiovascular disease (CVD), many people immediately think of high cholesterol. High cholesterol—a specific type of dyslipidemia or ...
Results trusted by over 18,000 functional wellness professionals
We’re the leading provider of specialty wellness lab testing because we develop our testing with rigorous, ongoing research by top clinical experts, doctors, and scientists.
-1.png?width=542&height=427&name=shutterstock_2371998817%201%20(1)-1.png)
.png?width=207&height=108&name=Group%201410104259%20(1).png)
The gold standard of accuracy in the lab industry
Our tests run on a proprietary 3Dense microchip technology platform that boasts unrivaled specificity and sensitivity. While most other labs carry only CLIA certification, we're CAP-accredited by the College of American Pathologists.
.png?width=487&height=356&name=Frame%201410104197%20(3).png)
.png?width=187&height=63&name=category%20Card%20text%20(1).png)
.png?width=202&height=63&name=category%20Card%20text%20(2).png)
Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
