What is Ara h 3 and Why Does the Food Zoomer Test for It?

Peanut seed storage protein

Ara h 3 is an 11S legumin seed storage protein from peanut that is commonly recognized by the immune system. Measuring IgA and IgG responses to Ara h 3 helps reveal whether peanut proteins are part of an individual's immune reactivity pattern and clarifies mucosal versus systemic signals.

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Ara h 3

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About Ara h 3

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About Ara h 3

Overview and History

Ara h 3 is classified as an 11S legumin seed storage protein derived from Arachis hypogaea (peanut). Biochemically it is an abundant, oligomeric protein that stores amino acids for seed germination and shows relative stability to heat and digestion. In immunology research Ara h 3 was identified as a dominant target of peanut-specific antibody responses. Its abundance and stability make it a useful marker for laboratories mapping antibody patterns to dietary proteins and peptides.

Interpreting Highs and Lows

Elevated IgA or IgG responses to Ara h 3 indicate measurable immune recognition of this peanut protein and reflect prior exposure or active antibody formation. A predominance of IgA suggests more mucosal (gut-associated) immune activity while higher IgG points toward systemic antibody response. Low or absent responses generally reflect limited recent exposure, immune tolerance, or that antibodies are directed at other peanut components. All results should be interpreted within the full Food Zoomer profile, including other peanut markers and overall isotype patterns.

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Ara h 3 is included in Food Zoomer to quantify peanut-specific antibody activity at both IgA and IgG levels. Assessing this marker helps providers identify whether peanut proteins contribute to broader immune patterns, distinguish mucosal versus systemic signals, and prioritize personalized dietary investigation and planning.

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Ara h 3 FAQs

What is Ara h 3 and why is it important?

Ara h 3 is a major protein present in peanuts that the immune system commonly recognizes. It serves as a nutrient storage protein in the seed, but its size and stability make it a frequent target for antibody responses. Detecting antibodies to Ara h 3 helps show whether peanut proteins are part of a person’s immune response pattern on the Food Zoomer.

What does it mean if my Ara h 3 levels are low?

Low Ara h 3 antibody levels typically indicate little measurable immune recognition of that peanut protein. This can reflect limited recent exposure, immune tolerance, or antibody focus on other peanut proteins instead. Low results are most informative when viewed alongside other Food Zoomer markers and clinical context.

What does it mean if my Ara h 3 levels are high?

High Ara h 3 antibody levels indicate a measurable immune response to this peanut protein. If IgA is relatively higher, that suggests mucosal (gut-associated) activity; if IgG is higher, that suggests more systemic antibody activity. Elevated responses can reflect prior exposure, cross-reactivity with related seed storage proteins, or a broader legume-related pattern and should be interpreted in the context of the complete panel and clinical history.

Why is Ara h 3 included in the Food Zoomer?

Measuring Ara h 3 helps providers detect peanut-specific immune signals within the broader dietary antibody profile. Including this marker supports pattern recognition across isotypes and peptide levels, aiding differentiation of mucosal versus systemic activity. That layered information improves precision when deciding which foods to investigate in personalized nutrition planning.

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