What is Ara h 5 and Why Does the Food Zoomer Test for It?

Peanut-derived profilin protein

Ara h 5 is a small profilin protein found in peanuts that the immune system can recognize. Profilins help regulate plant cell structure and are common across many fruits, vegetables, and pollens. Measuring Ara h 5 helps reveal immune responses to peanut profilin and patterns of cross-reactivity within the Food Zoomer panel.

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Ara h 5

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About Ara h 5

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About Ara h 5

Overview and History

Ara h 5 is classified as a plant profilin, a family of small actin‑binding proteins that stabilize the cytoskeleton in plant cells. Profilins are biochemically conserved across many plant species, typically heat‑labile and present in pollen, fruits, vegetables, and seeds. Ara h 5 was identified as one of several peanut proteins that can trigger immune recognition. Its clinical relevance comes from being a pan‑allergen: because profilins are widespread in plants, immune responses to Ara h 5 can overlap with responses to unrelated plant foods and pollens, making it useful for mapping cross-reactive immune patterns.

Interpreting Highs and Lows

Elevated antibody levels to Ara h 5 suggest measurable immune recognition of the peanut profilin and may point toward cross-reactivity with other plant‑derived proteins or pollens. Higher IgA may reflect mucosal or gut‑associated immune activity, while higher IgG may reflect broader systemic immune exposure. Low or absent levels indicate little or no measurable immune response to this specific profilin at the time of testing, but do not rule out responses to other peanut proteins or to other food families. Interpretation is most informative when seen alongside other markers on the Food Zoomer, including additional peanut peptides, pollen markers, and the dual IgA/IgG pattern.

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Ara h 5 is included to detect immune recognition of peanut profilin and to clarify cross-reactivity patterns among plant foods and pollens. As part of the Food Zoomer, it helps providers distinguish whether immune signals cluster around peanut profilin versus other peanut proteins, supporting targeted interpretation and personalized dietary planning.

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Ara h 5 FAQs

What is Ara h 5 and why is it important?

Ara h 5 is a profilin protein found in peanuts that the immune system can recognize. Because profilins are common across many plants and pollens, a response to Ara h 5 can be linked to cross‑reactivity with other fruits, vegetables, or pollens. Knowing whether Ara h 5 shows immune response helps clarify broader patterns in your Food Zoomer results.

What does it mean if my Ara h 5 levels are low?

Low Ara h 5 levels mean there is little or no measurable antibody response to this peanut profilin at the time of testing. This suggests the immune system is not currently recognizing this specific protein, but it does not rule out responses to other peanut components or to other plant allergens. Full-panel interpretation is needed to understand the overall immune pattern.

What does it mean if my Ara h 5 levels are high?

High Ara h 5 levels indicate measurable immune recognition of the peanut profilin and may reflect cross-reactivity with other plant foods or pollens. Patterns in IgA versus IgG can suggest whether the response is more mucosal (gut‑linked) or systemic, but the clinical meaning depends on the rest of your Food Zoomer profile and clinical context.

Why is Ara h 5 included in the Food Zoomer?

Ara h 5 helps map immune recognition of a peanut profilin that commonly cross-reacts with other plant proteins and pollens. Including it supports the panel's goal of identifying clustered immune patterns, distinguishing local versus systemic responses with IgA/IgG, and giving providers clearer data for personalized dietary planning.

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