What is Ara h 6 and Why Does the Food Zoomer Test for It?

Peanut seed storage protein

Ara h 6 is a peanut-derived seed storage protein that commonly elicits antibody responses. Measuring IgA and IgG to Ara h 6 helps indicate whether immune activity toward peanut proteins is localized at mucosal surfaces or reflects broader systemic engagement, aiding pattern-based interpretation.

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Ara h 6

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About Ara h 6

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About Ara h 6

Overview and History

Ara h 6 is one of several proteins isolated from Arachis hypogaea (peanut). Biochemically it belongs to the small, compact seed storage protein family; its structure is relatively stable to heat and digestion, which affects how the immune system recognizes and processes it. Ara h 6 was identified during molecular mapping of peanut proteins that interact with human antibodies. In the plant, these proteins serve as nutrient stores for seed germination; from an immune perspective, antibodies targeting Ara h 6 indicate recognition of a specific, stable peanut protein and contribute to the profile of food-specific immune activity.

Interpreting Highs and Lows

Higher IgA or IgG signals to Ara h 6 may reflect prior exposure and immune targeting of that peanut protein; IgA elevations tend to indicate activity at mucosal surfaces (for example, the gut) while IgG elevations reflect broader systemic antibody responses. Elevated reactivity is most informative when seen alongside other peanut or legume markers, as patterns across the panel clarify whether peanut proteins are a focal point of immune activity. Low or undetectable Ara h 6 antibodies can indicate limited recent exposure, immune tolerance, or that antibody recognition is below the test's detection threshold. Any single result should be interpreted in the context of symptoms, exposure history, and the full Food Zoomer profile.

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Ara h 6 is included to detect immune targeting of a specific, stable peanut protein. Paired IgA and IgG measurements at the peptide level help distinguish gut-linked versus systemic peanut responses and reveal whether peanut reactivity clusters with other dietary markers, supporting personalized nutrition planning.

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Ara h 6 FAQs

What is Ara h 6 and why is it important?

Ara h 6 is a peanut seed protein that the immune system can recognize. Antibodies against Ara h 6 show that the body has mounted a response to that peanut protein. Tracking this marker alongside other peanut-related proteins helps providers see whether immune activity is focused on peanuts and whether it is primarily mucosal or systemic.

What does it mean if my Ara h 6 levels are low?

Low Ara h 6 antibody levels generally mean there is little measurable immune response to that specific peanut protein. This can reflect limited recent exposure, immune tolerance, or antibody levels below the test's detection. Low results are best interpreted with your symptoms, dietary history, and other Food Zoomer markers to understand the full pattern.

What does it mean if my Ara h 6 levels are high?

Higher Ara h 6 antibody levels suggest the immune system has been exposed to and is reacting to that peanut protein. Elevated IgA points more to mucosal or gut-associated activity, while elevated IgG indicates systemic antibody involvement. Determining the significance of a high result requires comparison with other peanut markers, symptom patterns, and the dual-isotype profile in the full panel.

Why is Ara h 6 included in the Food Zoomer?

Including Ara h 6 provides precise detection of immune activity aimed at a specific peanut protein. Combined with peptide-level detail and dual IgA/IgG data, it helps providers identify peanut-related patterns, distinguish mucosal versus systemic responses, and integrate results into targeted nutrition planning.

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