What is Ara h 8 and Why Does the Food Zoomer Test for It?

Peanut PR-10 cross-reactive protein

Ara h 8 is a peanut-derived PR-10 (Bet v 1–like) protein that can trigger immune recognition, often via cross-reactivity with certain pollen proteins. Measuring IgA and IgG responses to Ara h 8 helps reveal whether the immune system specifically recognizes this peanut protein and clarifies patterns of food–pollen immune reactivity within the Food Zoomer panel.

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Ara h 8

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About Ara h 8

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About Ara h 8

Overview and History

Ara h 8 belongs to the PR-10 family of plant pathogenesis-related proteins and is structurally similar to the birch pollen protein Bet v 1. These are small, soluble proteins involved in plant defense and are biochemically distinct from peanut storage proteins; they tend to be heat- and digestion-labile. Ara h 8 was identified as a peanut protein frequently recognized by the human immune system and notable for its tendency to cross-react with pollen-derived PR-10 proteins. Its biological significance in testing lies in distinguishing PR-10–type immune recognition from responses directed at peanut storage proteins, giving finer detail about which peanut components the immune system targets.

Interpreting Highs and Lows

Elevated IgA or IgG signals to Ara h 8 may indicate prior immune exposure and specific recognition of the PR-10 peanut protein, and can reflect cross-reactive responses with related pollen proteins. Higher mucosal IgA versus systemic IgG may suggest a stronger gut-associated immune signal, while the reverse supports broader systemic recognition. Low or absent Ara h 8 responses suggest lack of immune recognition of this particular PR-10 protein but do not rule out reactivity to other peanut proteins or food components. Interpretation is most reliable when considered alongside other Food Zoomer markers, clinical history, and exposure patterns.

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Ara h 8 is included in Food Zoomer to capture PR-10–type immune recognition within the peanut domain and to detect possible cross-reactivity with pollen proteins. Measuring this marker alongside other peanut proteins helps providers map specific immune patterns and refine personalized dietary and reintroduction plans based on the panel’s broader IgA/IgG profile.

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Ara h 8 FAQs

What is Ara h 8 and why is it important?

Ara h 8 is a specific peanut protein from the PR-10 family that shares structure with certain pollen proteins. It matters because immune recognition of Ara h 8 often reflects cross-reactive responses, so its presence can help explain links between peanut exposure and pollen-related immune patterns. Knowing whether Ara h 8 is recognized helps distinguish different types of peanut-related immune activity.

What does it mean if my Ara h 8 levels are low?

Low Ara h 8 IgA/IgG levels generally mean the immune system does not show notable recognition of this particular peanut PR-10 protein. That does not exclude immune responses to other peanut components or to unrelated foods. Low results are best interpreted together with the full Food Zoomer profile and clinical context.

What does it mean if my Ara h 8 levels are high?

Higher Ara h 8 IgA or IgG suggests immune recognition of the peanut PR-10 protein and may point to cross-reactivity with similar pollen proteins. Elevated signals can reflect mucosal (IgA) or systemic (IgG) activity, but clinical context and other panel markers are needed to clarify the pattern and relevance.

Why is Ara h 8 measured in the Food Zoomer?

Including Ara h 8 helps separate PR-10–type peanut recognition from responses to peanut storage proteins and other food domains. This distinction improves pattern analysis in the Food Zoomer, supporting more precise interpretation of immune reactivity and helping providers tailor dietary planning based on combined IgA/IgG results.

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