What is Lipovitellin and Why Does the Food Zoomer Test for It?

Egg-yolk lipid transport protein

Lipovitellin is a major egg‑yolk lipoprotein that transports lipids and fat‑soluble nutrients. Measuring IgA and IgG responses to lipovitellin helps show whether the immune system is recognizing egg‑yolk components at the mucosal (gut) level, the systemic level, or both, offering useful context in food‑immune patterns.

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Lipovitellin

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About Lipovitellin

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About Lipovitellin

Overview and History

Lipovitellin is a high‑molecular‑weight lipoprotein derived from vitellogenin and is the dominant storage protein in egg yolk of avian species. Biochemically it belongs to the lipoprotein family, binding lipids, vitamins, and other hydrophobic nutrients to support early embryonic growth. Historically studied in reproductive and nutritional biology, lipovitellin is also a well‑characterized food antigen. In immunoassays it can be targeted as a purified protein or broken into peptide fragments to detect specific IgA and IgG antibody binding, giving peptide‑level insight into immune recognition of egg‑yolk components.

Interpreting Highs and Lows

Elevated antibody responses to lipovitellin may indicate increased immune recognition or reactivity to egg‑yolk components. A predominant IgA signal suggests mucosal (gut) immune activity, while a stronger IgG signal suggests broader systemic immune engagement; elevations can reflect recent exposure, repeated intake, or cross‑reactivity with related proteins. Low or absent antibody responses generally indicate limited immune recognition of lipovitellin, which can reflect true tolerance, low dietary exposure, or timing of sampling. Any single marker is most informative when evaluated alongside the Food Zoomer panel and clinical history to identify patterns across foods and immune isotypes.

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Lipovitellin is included because egg yolk is a common dietary antigen and a frequent component of mixed foods. Measuring IgA and IgG against lipovitellin helps detect egg‑yolk–specific immune patterns and contributes to domain‑level clustering that supports more precise, personalized dietary decision‑making.

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Lipovitellin FAQs

What is Lipovitellin and why is it important?

Lipovitellin is the main fat‑carrying protein in egg yolk that supplies lipids and fat‑soluble nutrients. The immune system can form antibodies that bind this protein, and those antibodies are measurable in the Food Zoomer. Detecting such responses helps providers see whether egg‑yolk components align with patterns of digestive, skin, or inflammatory symptoms.

What does it mean if my Lipovitellin levels are low?

Low antibody levels to lipovitellin usually mean there is little or no immune recognition of egg‑yolk proteins—this can reflect tolerance, limited recent exposure, or timing of the test. Low results are one piece of the puzzle and are best interpreted with other Food Zoomer markers and clinical information.

What does it mean if my Lipovitellin levels are high?

Higher antibody levels to lipovitellin suggest the immune system is recognizing egg‑yolk components. Elevated IgA points toward mucosal (gut) activity, while elevated IgG indicates wider systemic immune engagement; elevated lipovitellin responses are most informative when seen alongside other egg‑related markers and overall panel patterns.

Why is Lipovitellin included in the Food Zoomer?

Because egg yolk is a common dietary protein, lipovitellin is measured to identify egg‑yolk–specific immune activity. Its inclusion, measured as both IgA and IgG and at peptide resolution, helps providers detect domain‑level clusters and refine personalized nutrition strategies.

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