What is GSTM1 (rs366631) and Why Does the Cellular Zoomer Test for It?

Glutathione detox enzyme variant

GSTM1 (rs366631) is a genetic variant in the GSTM1 gene, which encodes a glutathione S‑transferase involved in neutralizing reactive compounds. Measuring this variant helps contextualize inherited antioxidant and detox capacity alongside urine markers of oxidative stress and detox intermediates.

View Cellular Zoomer

GSTM1 (rs366631)

Quality and Security

High-quality testing run in a CLIA-certified and CAP-accredited lab in Santa Clara, California.

fortified-health-HIPAA-compliance-pqgjtx4popoe2n0arp68hrz8h2as5rlhgng5b2srk8 1

About GSTM1 (rs366631)

${ activeTab.tab_content.text }

View ${ activeTab.tab_content.btn_label }

About GSTM1 (rs366631)

Overview and History

GSTM1 belongs to the glutathione S‑transferase (GST) mu family, a group of phase II enzymes that help attach glutathione to reactive molecules, making them easier for cells to handle and remove. The rs366631 label refers to a specific single nucleotide polymorphism (SNP) in the GSTM1 region that has been examined in toxicology and redox biology research. Genetic variation in GSTM1 has attracted attention because changes in the gene can influence enzyme expression or activity, which in turn affects how cells manage electrophiles, environmental chemicals, and some metabolic byproducts. Researchers study variants like rs366631 to understand patterns of antioxidant resilience and susceptibility to oxidative biochemical signals.

Interpreting Highs and Lows

Variants associated with relatively higher predicted GSTM1 activity may be associated with a greater capacity to conjugate and clear reactive compounds; within a full panel this can align with lower oxidative damage markers or faster detox intermediate turnover. Conversely, variants linked to lower predicted activity or reduced expression may be associated with diminished conjugation capacity and could correspond with higher oxidative markers or accumulation of certain detox intermediates. Interpretation depends on the overall Cellular Zoomer profile — genotype alone describes inherited potential, while urine oxidative and detox markers reflect current biochemical load and exposures.

Featured Test

GSTM1 (rs366631) is included in the Cellular Zoomer as part of the antioxidant genetics module. It helps connect inherited variation in a key detox enzyme with measured oxidative damage and detoxification metabolites, improving pattern recognition and personalization of metabolic and redox interpretation.

View Cellular Zoomer

GSTM1 (rs366631) FAQs

What is GSTM1 (rs366631) and why is it important?

GSTM1 (rs366631) is a specific genetic variation in the GSTM1 gene, which encodes an enzyme that helps neutralize reactive molecules by linking them to glutathione. It’s important because inherited differences can influence how efficiently cells handle oxidative byproducts and some environmental chemicals. Knowing the variant helps put urine markers of oxidative stress and detox metabolism into genetic context.

What does it mean if my GSTM1 (rs366631) levels are low?

A genotype associated with lower GSTM1 activity suggests reduced predicted capacity to conjugate and clear certain reactive compounds. In the context of the Cellular Zoomer, that pattern may align with higher oxidative damage markers or slower clearance of detox intermediates, especially when combined with environmental exposures or metabolic signals.

What does it mean if my GSTM1 (rs366631) levels are high?

A genotype associated with higher GSTM1 activity suggests greater predicted capacity for glutathione‑dependent conjugation of reactive molecules. On its own this is an inherited tendency; meaningful interpretation requires comparing the genetic result with urine oxidative markers, detox intermediates, and exposure history from the full Cellular Zoomer report.

Why is GSTM1 (rs366631) included in the Cellular Zoomer?

GSTM1 (rs366631) is part of the panel’s antioxidant genetics group so clinicians can link inherited detox potential to measured oxidative damage and detox metabolites. This pairing improves precision in detecting patterns of redox strain, exposure impact, and metabolic bottlenecks, supporting more tailored interpretation of cellular resilience.

Browse Articles

How Histamine Affects Mental Health and Cognitive Function

When most people think of histamine, they picture allergy symptoms, sneezing, hives, and congestion. But histamine is far more than an allergy molecul...

Brendan Vermeire

Sep 9, 2025

Neural Health Longevity

How Toxin Exposure Impacts Your Cardiometabolic Health

A common theme among many of my nutrition clients is that despite eating well, staying active, and managing stress, they feel worn down, inflamed, and...

Leslie Weidner, RDN

Aug 13, 2025

Cardiovascular Health Toxins Longevity

Why Hormone Metabolites Are the Missing Link in Integrative Care

Hormone imbalances are among the most common complaints we hear as functional and integrative medical practitioners. However, many of us are missing a...

Logan Morse, PharmD, ABAAHP, FAAFRM, FACA

Jul 14, 2025

Hormones Longevity

How Oxidative Stress Influences Biological Aging

Oxidative stress is a crucial determinant of cellular function and longevity, representing the imbalance between free radicals and antioxidants in the...

Tyana Smith, MA

Jul 2, 2025

Longevity

About Vibrant:

The Experts Behind  Every Test

Our team is built on collaboration across disciplines to advance the science of wellness and longevity. At Vibrant Wellness, lab scientists, technologists, clinical researchers, doctors, practitioners, longevity advisors, engineers, and regulatory experts work side by side to transform diagnostics.

By uniting diverse expertise under one mission, we pioneer precision testing that empowers providers to uncover root causes, personalize care plans, and optimize patient health outcomes. Every test we develop reflects this commitment—to push boundaries in functional medicine, deliver clear, actionable insights, and support clinicians in helping patients live healthier, longer lives.

View All Tests

Results trusted by over 18,000 functional wellness professionals

We’re the leading provider of specialty wellness lab testing because we develop our testing with rigorous, ongoing research by top clinical experts, doctors, and scientists.

The gold standard of accuracy in  the lab industry

Our tests run on a proprietary 3Dense microchip technology platform that boasts unrivaled specificity and sensitivity. While most other labs carry only CLIA certification, we're CAP-accredited by the College of American Pathologists.

Our Clinical Support Team

We understand that patient care doesn't end with diagnosis. To achieve Vibrant health, patients need clinical support and
obtainable lifestyle changes. Our clinical support team helps providers make informed treatment recommendations, resulting in  better patient outcomes.

Mary Beth Augustine

DCN, RDN, FAND- Lead Clinical Educator

Suzanne Barker

MS, RDN, LD, CTTS, CGP- Clinical Educator

Suzette Garcia

MSc- MHNE- Clinical Educator

Brooke Mader Ganev

MS, CNS, LDN, FDN- Clinical Educator

Adair Anderson

MS, RDN, LDN- Clinical Educator

Lillie Luu Nguyen

DCN, CNS, LDN- Clinical Educator

Jason Barker

ND- Clinical Educator

Emaline Brown

ND- Clinical Educator

Dana Filatova

DCN, CNS, LDN- Clinical Educator

Jessy Dhanjal

ND- Clinical Educator

Nour Amri

MS, LDN, CNS, CKNS- Clinical Educator

Ready to Elevate Your Approach to Precision Wellness?

At Vibrant Wellness, we’re redefining the future of diagnostics—making complex science clear, accessible, and actionable. Whether you're a provider advancing personalized care or a patient seeking data-driven answers, our precision testing gives you the clarity to make informed decisions. Experience the next generation of functional medicine through clinically validated insights and seamless testing solutions.

Become a Provider

Find a Provider