Phospholipid-targeting autoantibody
Quality and Security
High-quality testing run in a CLIA-certified and CAP-accredited lab in Santa Clara, California.
About Cardiolipin
${ activeTab.tab_content.text }
Loading...
About Cardiolipin
Overview and History
Cardiolipin is a phospholipid concentrated in inner mitochondrial membranes and bacterial membranes; in the clinical lab context we usually measure antibodies that bind cardiolipin (anti‑cardiolipin antibodies). These antibodies are a class of autoantibodies that recognize phospholipid structures or phospholipid–protein complexes, and they are detected by immunoassays.
Historically, cardiolipin reactivity was first noted in serologic tests and later recognized as part of broader immune patterns involving phospholipid binding proteins. Biologically, cardiolipin itself helps maintain membrane structure and supports energy‑related processes; antibodies that target cardiolipin reflect immune reactivity directed at those membrane components or associated protein complexes.
Interpreting Highs and Lows
Elevated anti‑cardiolipin antibody levels suggest immune reactivity against membrane phospholipids or phospholipid–protein complexes and are often interpreted as one piece of evidence for altered vascular and platelet signaling or enhanced immune activation. Low or undetectable levels generally indicate the absence of measurable anti‑cardiolipin reactivity at the time of testing and are a common finding in people without phospholipid‑targeted immune activity. Results are most informative when interpreted alongside other Immune Zoomer markers and clinical history, since single markers rarely provide a complete picture on their own.
Featured Test
Cardiolipin is included in the Immune Zoomer to evaluate phospholipid‑targeted immune activity within the panel’s Vascular and Immune‑Signaling domain. Measuring anti‑cardiolipin adds information about immune patterns that affect membrane and platelet signaling, helping clinicians connect vascular‑related symptoms to broader immune activity and prioritize targeted evaluation.
Related Articles
For many women, the postpartum phase is physically exhausting and emotionally raw. And beneath the surface, the immune system is in flux, just like a ...
Understanding Menstrual-Driven Immune Flares and Clinical Testing Strategies Many women with autoimmune conditions report that their autoimmune sympto...
If you’ve spent any time around teenagers, it might seem like they can deal with just about anything — crappy diets, late nights, emotional stress, an...
Gluten, a protein found in wheat, barley, rye, and related grains, is a staple in many diets worldwide. And for many individuals, it’s harmless to con...
Results trusted by over 18,000 functional wellness professionals
We’re the leading provider of specialty wellness lab testing because we develop our testing with rigorous, ongoing research by top clinical experts, doctors, and scientists.
-1.png?width=542&height=427&name=shutterstock_2371998817%201%20(1)-1.png)
.png?width=207&height=108&name=Group%201410104259%20(1).png)
The gold standard of accuracy in the lab industry
Our tests run on a proprietary 3Dense microchip technology platform that boasts unrivaled specificity and sensitivity. While most other labs carry only CLIA certification, we're CAP-accredited by the College of American Pathologists.
.png?width=487&height=356&name=Frame%201410104197%20(3).png)
.png?width=187&height=63&name=category%20Card%20text%20(1).png)
.png?width=202&height=63&name=category%20Card%20text%20(2).png)
Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
