Amyloid beta-targeting autoantibody
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About Anti-Amyloid beta (25–35)
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About Anti-Amyloid beta (25–35)
Overview and History
Anti-Amyloid beta (25–35) is an autoantibody directed against residues 25–35 of the amyloid beta peptide, a cleavage product of amyloid precursor protein (APP). The 25–35 fragment is commonly used in laboratory studies as a model peptide with neuroactive properties; antibodies targeting this fragment reflect peripheral immune recognition of amyloid-related epitopes.
Amyloid beta peptides and the immune responses they elicit have been studied in neurological research for decades. Antibodies to amyloid peptides have been reported in clinical and experimental settings and are of interest because they can indicate peripheral immune engagement, possible peptide clearance activity, or interactions between systemic immunity and central nervous system processes.
Interpreting Highs and Lows
Higher anti-Amyloid beta (25–35) levels may indicate increased peripheral immune recognition of amyloid-related peptides, which can occur alongside broader neuroimmune activation or when antigen exposure or barrier permeability is altered. Such elevations are a pattern to interpret alongside markers of inflammation, blood–brain barrier integrity, and other neural autoantibodies.
Low or undetectable levels generally indicate little measurable antibody response to this specific peptide fragment—this can reflect low antigen exposure, immune tolerance, or antibodies below assay sensitivity. Absence of a measurable antibody does not rule out other neuroimmune processes; interpretation is most meaningful within the full Neural Zoomer panel and clinical context.
Featured Test
This marker is included in the Neural Zoomer’s brain autoimmunity and inflammation domain to capture immune responses directed at amyloid peptides. It helps providers detect patterns of peripheral immune recognition that, together with barrier and inflammation markers, add depth to neuroimmune profiling and support more personalized, pattern-based clinical interpretation.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
