Endoplasmic reticulum chaperone autoantibody
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About Anti-Glucose regulated protein 78 (GRP78)
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About Anti-Glucose regulated protein 78 (GRP78)
Overview and History
Anti-GRP78 is classified as an autoantibody that targets the 78-kDa glucose-regulated protein (GRP78/HSPA5), a well-characterized ER chaperone. GRP78 was identified for its role in the unfolded protein response and is central to protein folding, quality control, and cellular responses to stress.
Under stress, GRP78 can redistribute and appear on cell surfaces, where it can interact with immune components and endothelial cells. Those interactions are of interest because surface or extracellular GRP78 may relate to processes that influence barrier properties, immune recognition, and cell signaling in neural tissues.
Interpreting Highs and Lows
Elevated anti-GRP78 levels may reflect immune engagement with GRP78-expressing cells or exposed GRP78, which has been associated in studies with patterns of barrier-related immune activity and inflammation. Such elevation can signal a pattern worth investigating alongside other neuroimmune and barrier markers.
Low or undetectable anti-GRP78 simply indicates a lack of measurable antibody in the tested sample; it does not rule out barrier stress or other immune processes. Results are most informative when interpreted with the full Neural Zoomer panel and clinical context, including timing and other marker patterns.
Featured Test
GRP78 is included in the Neural Zoomer to evaluate blood–brain barrier–related immune patterns and cellular stress signals. As part of the barrier integrity domain, anti-GRP78 adds context about possible immune interactions with barrier and endothelial proteins, helping providers map neuroimmune patterns and prioritize targeted follow-up within a personalized assessment.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
