Neuronal onconeural autoantibody
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About Anti-Ma
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About Anti-Ma
Overview and History
Anti-Ma antibodies target Ma family proteins (commonly called PNMA1 and PNMA2), which are intracellular neuronal proteins involved in RNA binding and neuronal regulatory processes. Biochemically, these antibodies are classified as onconeural or neuronal autoantibodies because they recognize neuronal antigens that can also be expressed by some tumors.
Anti-Ma responses were identified in the context of paraneoplastic neurological research in the 1990s and have since been used as markers of immune activity directed at neuronal tissue. Detectable Anti-Ma reflects immune recognition of intracellular neuronal components rather than a direct measure of neuronal damage itself.
Interpreting Highs and Lows
Elevated Anti-Ma levels may indicate an immune response targeting intracellular neuronal proteins and are often interpreted as a marker of neuroimmune activity or paraneoplastic-associated immune patterns; they can be associated with symptoms affecting memory, sleep, movement, or mood. Low or undetectable Anti-Ma levels suggest that this specific antibody is not contributing to the immune pattern detected, but absence of Anti-Ma does not exclude other immune mechanisms. Interpretation should always use the full Neural Zoomer panel and clinical context to map patterns across multiple neural targets.
Featured Test
Anti-Ma is included in the Neural Zoomer to detect neuronal-directed immune activity within the brain autoimmunity domain. Measuring Anti-Ma helps distinguish patterns that may point toward paraneoplastic-associated immune signaling versus other neuroimmune profiles, refining the overall picture for more personalized evaluation.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
