Neuromuscular junction autoantibody
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About Anti-Muscle specific kinase (MuSK)
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About Anti-Muscle specific kinase (MuSK)
Overview and History
Anti-MuSK antibodies are immunoglobulin autoantibodies directed against muscle-specific kinase (MuSK), a receptor tyrosine kinase located on the postsynaptic membrane of the neuromuscular junction. Biochemically they are usually IgG-class antibodies detected in blood using sensitive immunoassays.
MuSK was identified through research into immune-mediated disruption of neuromuscular signaling; its role is to organize and stabilize acetylcholine receptor clusters and other scaffold proteins so nerves efficiently trigger muscle fibers. When immune activity targets MuSK, the molecular architecture that supports fast, reliable muscle activation can be altered, making this marker clinically relevant for assessing neuromuscular immune patterns.
Interpreting Highs and Lows
Elevated anti-MuSK levels suggest an immune response directed at the MuSK protein and may be associated with patterns of impaired neuromuscular signaling, such as fluctuating muscle weakness, fatigue, or difficulty with sustained muscle use. Interpretation requires clinical context and correlation with symptoms and other test results from the Neural Zoomer panel.
Low or undetectable anti-MuSK levels indicate no measurable antibody against MuSK in the sample tested; this does not exclude other immune activity, alternative neuromuscular mechanisms, or non-immune causes of muscle symptoms. Results are most informative when reviewed alongside the full panel and clinical findings.
Featured Test
Anti-MuSK is included in the Neural Zoomer’s neuromuscular disorders domain to flag immune activity that may affect nerve‑to‑muscle signaling. Measuring this antibody helps providers distinguish patterns of neuromuscular immune involvement from other contributors to muscle fatigue or variability, supporting more targeted follow-up and personalized evaluation.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
