Purkinje cell–targeting antibody
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About Anti-Purkinje cell
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About Anti-Purkinje cell
Overview and History
Anti-Purkinje cell antibodies are immunoglobulins that recognize proteins expressed by Purkinje neurons in the cerebellar cortex. Purkinje cells are large inhibitory neurons that form the primary output of the cerebellar cortex and play key roles in motor coordination, timing, and certain aspects of cognitive-motor integration.
These antibodies were identified in studies of immune-related cerebellar dysfunction and are used in research and clinical testing as markers of cerebellar-directed immune activity. Laboratory detection uses techniques such as immunofluorescence and high-sensitivity immunoassays; the specific antigen targeted and antibody class (for example, IgG) affect interpretation and clinical relevance.
Interpreting Highs and Lows
Elevated anti-Purkinje levels suggest measurable immune reactivity directed at cerebellar neurons, a pattern that can be associated with changes in coordination, balance, speech timing, or motor control. Low or undetectable levels indicate that this specific antibody is not present at appreciable levels in the blood sample, but do not exclude other immune or non-immune causes of symptoms. Results gain meaning when interpreted alongside clinical findings and the broader Neural Zoomer panel, which evaluates multiple neuroimmune pathways.
Featured Test
Neural Zoomer includes Anti-Purkinje cell to detect immune targeting of cerebellar neurons and to map cerebellar involvement within the panel’s broader neuroimmune framework. This marker helps providers compare cerebellar-directed immune activity with other domains—such as inflammation, blood–brain barrier markers, and peripheral neuropathy—to guide focused evaluation and monitoring.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
