Nuclear double-stranded DNA antigen
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High-quality testing run in a CLIA-certified and CAP-accredited lab in Santa Clara, California.
About Double-stranded DNA (dsDNA)
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About Double-stranded DNA (dsDNA)
Overview and History
dsDNA refers to the two complementary strands of DNA that carry genetic information in the cell nucleus (and in smaller amounts in mitochondria). Biochemically it is a nucleic acid; clinically, tests commonly measure antibodies that bind dsDNA rather than the DNA itself.
Antibodies to nuclear components, including dsDNA, were recognized early in studies of immune responses to self-antigens. Biologically, dsDNA’s core role is information storage and transmission; when cells die or release nuclear content, exposed dsDNA can become an immune target and a signal of altered immune tolerance.
Interpreting Highs and Lows
Elevated levels of antibodies against dsDNA may indicate increased immune reactivity to nuclear material and often accompany broader systemic immune activation or organ-focused immune processes. Low or undetectable levels are common and can reflect the absence of an anti-dsDNA response, or that immune activity is directed at other targets. Interpretation is most meaningful within the full Immune Zoomer panel and in clinical context, since assay methods and timing can affect results.
Featured Test
dsDNA is included in the Immune Zoomer as a core systemic immune marker. It evaluates immune targeting of nuclear material and helps identify patterns of broad immune activation. Combined with other autoantibodies across organ systems, it assists providers in prioritizing further evaluation and personalizing monitoring strategies.
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Our tests run on a proprietary 3Dense microchip technology platform that boasts unrivaled specificity and sensitivity. While most other labs carry only CLIA certification, we're CAP-accredited by the College of American Pathologists.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
