Nuclear spliceosome autoantigen
Quality and Security
High-quality testing run in a CLIA-certified and CAP-accredited lab in Santa Clara, California.
About Sm/RNP
${ activeTab.tab_content.text }
Loading...
About Sm/RNP
Overview and History
Sm/RNP describes proteins and associated small nuclear RNAs that form part of the spliceosome complex, the cellular machinery that removes introns from pre-mRNA. Biochemically these are small nuclear ribonucleoproteins (snRNPs) including the Sm core proteins and U1‑RNP components.
Historically, Sm and RNP targets were identified through serologic studies that showed circulating antibodies in people with systemic immune symptoms. Functionally, Sm/RNP complexes are essential for RNA processing and normal gene expression; immune targeting of these nuclear components reflects a loss of immune tolerance to intracellular spliceosomal proteins.
Interpreting Highs and Lows
Elevated levels of antibodies against Sm/RNP suggest the immune system is recognizing and binding nuclear spliceosomal proteins, which can be part of a broader pattern of systemic immune activation affecting multiple tissues. Low or undetectable levels indicate no measurable antibody response against these specific nuclear targets, but do not rule out other immune activity elsewhere. Interpretation should always consider Sm/RNP results alongside the full Immune Zoomer panel, clinical history, and other lab findings to map overall immune patterns.
Featured Test
Sm/RNP is included in Immune Zoomer to evaluate systemic immune targeting of nuclear RNA‑processing proteins. As a systemic immune marker, it helps reveal multi‑system reactivity patterns and contributes to a more complete map of immune signals that clinicians use to prioritize further evaluation and personalized care planning.
Related Articles
For many women, the postpartum phase is physically exhausting and emotionally raw. And beneath the surface, the immune system is in flux, just like a ...
Understanding Menstrual-Driven Immune Flares and Clinical Testing Strategies Many women with autoimmune conditions report that their autoimmune sympto...
If you’ve spent any time around teenagers, it might seem like they can deal with just about anything — crappy diets, late nights, emotional stress, an...
Gluten, a protein found in wheat, barley, rye, and related grains, is a staple in many diets worldwide. And for many individuals, it’s harmless to con...
Results trusted by over 18,000 functional wellness professionals
We’re the leading provider of specialty wellness lab testing because we develop our testing with rigorous, ongoing research by top clinical experts, doctors, and scientists.
-1.png?width=542&height=427&name=shutterstock_2371998817%201%20(1)-1.png)
.png?width=207&height=108&name=Group%201410104259%20(1).png)
The gold standard of accuracy in the lab industry
Our tests run on a proprietary 3Dense microchip technology platform that boasts unrivaled specificity and sensitivity. While most other labs carry only CLIA certification, we're CAP-accredited by the College of American Pathologists.
.png?width=487&height=356&name=Frame%201410104197%20(3).png)
.png?width=187&height=63&name=category%20Card%20text%20(1).png)
.png?width=202&height=63&name=category%20Card%20text%20(2).png)
Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
