Spliceosome-associated autoantigen
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About U1-snRNP 68/70 kDa
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About U1-snRNP 68/70 kDa
Overview and History
U1-snRNP 68/70 kDa refers to two closely related proteins (~68 and ~70 kilodaltons) that are integral parts of the U1 small nuclear ribonucleoprotein (snRNP) complex. The U1-snRNP is a key component of the spliceosome machinery that recognizes the 5' splice site and helps remove introns from pre-messenger RNA during gene expression.
Autoantibodies directed at U1-snRNP were identified in autoimmune serology research and have long been used as markers of immune recognition of nuclear spliceosomal proteins. Their detection reflects immune reactivity against intracellular nuclear components and is informative when assessed alongside other systemic immune markers.
Interpreting Highs and Lows
Elevated levels of autoantibodies to U1‑snRNP 68/70 kDa suggest the immune system is recognizing spliceosomal/nuclear proteins and often occurs together with other systemic immune markers; this pattern can point to nuclear-directed autoimmunity or overlap-type immune activity. Low or undetectable levels mean that this specific autoantibody is not prominent at the time of testing; absence does not exclude immune activity against other targets or the possibility of early or evolving antibody responses. Results are most useful when interpreted within the full Immune Zoomer panel and the clinical context to identify meaningful patterns across systems.
Featured Test
U1‑snRNP 68/70 kDa is included in the Immune Zoomer to detect spliceosome-targeting autoantibodies as part of the Systemic Immune Activity domain. Its measurement helps map nuclear-directed immune patterns, contributing to multi-marker pattern recognition that supports personalized monitoring, risk assessment, and targeted clinical investigation.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
