Spliceosomal RNA-binding protein
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About U1-snRNP C
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About U1-snRNP C
Overview and History
U1-snRNP C is one subunit of the U1 small nuclear ribonucleoprotein (snRNP) complex, a multi-protein and RNA assembly that recognizes the 5' splice site of pre-mRNA. Biochemically it is an RNA-binding protein involved in spliceosome assembly and accurate removal of introns during messenger RNA processing.
Historically, components of the U1-snRNP complex were identified as autoantigens in studies of systemic immune reactivity. Because the C protein is a defined molecular target, antibodies against it have been used in research and clinical testing to map immune responses directed at nuclear RNA–protein complexes and to study patterns of autoimmune activity.
Interpreting Highs and Lows
Elevated autoantibody levels to U1-snRNP C may indicate immune recognition of spliceosomal components and could be part of a broader pattern of nuclear autoimmunity. Such elevation is best interpreted as a marker of immune activity rather than a standalone diagnosis and should be considered with other serologic and clinical findings.
Low or undetectable levels generally indicate the absence of a measurable antibody response to this specific spliceosomal subunit at the time of testing. A low result does not rule out immune activity against other targets or earlier/later changes in immune patterns; serial testing and full-panel context improve interpretation.
Featured Test
U1-snRNP C is included in the Immune Zoomer because antibodies to spliceosomal proteins are informative markers of systemic immune reactivity. Within the panel, this marker helps map nuclear-directed autoantibody patterns, contributing to a clearer, tissue- and pathway-specific picture that clinicians use to prioritize further evaluation and monitoring.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
